Glutamic-oxaloacetic

Glutamic-oxaloacetic transaminase (GOT), also known as aspartate transaminase (AST), is an enzyme that is essential in the metabolism of amino acids. It catalyzes the reversible conversion of aspartate and alpha-ketoglutarate to oxaloacetate and glutamate with the help of pyridoxal 5′-phosphate (PLP). GOT is found in a variety of tissues, including the liver, heart, and skeletal muscle. Its levels in the blood, however, are primarily associated with liver function, as they can indicate liver damage or disease. GOT levels in the blood are frequently elevated in conditions such as viral hepatitis, alcohol-induced liver disease, and cirrhosis. GOT is also used to diagnose other medical conditions, such as myocardial infarction and muscle injury. Elevated levels of the enzyme are detected in the blood in these cases, indicating damage to the heart or muscle tissue. GOT is used in a variety of industrial processes in addition to diagnostic applications. Because it can catalyze the synthesis of various amino acid-derived compounds, the enzyme is used in the production of flavors and fragrances. GOT has also been studied for its potential use in the production of chiral compounds, which are important building blocks in the pharmaceutical industry.